KEGG   Homo sapiens (human): 2073
Entry
2073              CDS       T01001                                 
Symbol
ERCC5, COFS3, ERCC5-201, ERCM2, UVDR, XPG, XPGC
Name
(RefSeq) ERCC excision repair 5, endonuclease
  KO
K10846  DNA excision repair protein ERCC-5
Organism
hsa  Homo sapiens (human)
Pathway
hsa03420  Nucleotide excision repair
Network
nt06502  Nucleotide excision repair
  Element
N01431  Core NER reaction
Disease
H00076  Cockayne syndrome
H00403  Disorders of nucleotide excision repair
H01428  Xeroderma pigmentosum
H02570  Cerebro-oculo-facio-skeletal syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03420 Nucleotide excision repair
    2073 (ERCC5)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    2073 (ERCC5)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    Other NER factors
     2073 (ERCC5)
SSDB
Motif
Pfam: XPG_N XPG_I 5_3_exonuc EF-G-binding_N
Other DBs
NCBI-GeneID: 2073
NCBI-ProteinID: NP_000114
OMIM: 133530
HGNC: 3437
Ensembl: ENSG00000134899
UniProt: P28715
Structure
Position
13:102846032..102875995
AA seq 1186 aa
MGVQGLWKLLECSGRQVSPEALEGKILAVDISIWLNQALKGVRDRHGNSIENPHLLTLFH
RLCKLLFFRIRPIFVFDGDAPLLKKQTLVKRRQRKDLASSDSRKTTEKLLKTFLKRQAIK
TAFRSKRDEALPSLTQVRRENDLYVLPPLQEEEKHSSEEEDEKEWQERMNQKQALQEEFF
HNPQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRRTLFEAMPEESDDFSQYQLKGLLKK
NYLNQHIEHVQKEMNQQHSGHIRRQYEDEGGFLKEVESRRVVSEDTSHYILIKGIQAKTV
AEVDSESLPSSSKMHGMSFDVKSSPCEKLKTEKEPDATPPSPRTLLAMQAALLGSSSEEE
LESENRRQARGRNAPAAVDEGSISPRTLSAIKRALDDDEDVKVCAGDDVQTGGPGAEEMR
INSSTENSDEGLKVRDGKGIPFTATLASSSVNSAEEHVASTNEGREPTDSVPKEQMSLVH
VGTEAFPISDESMIKDRKDRLPLESAVVRHSDAPGLPNGRELTPASPTCTNSVSKNETHA
EVLEQQNELCPYESKFDSSLLSSDDETKCKPNSASEVIGPVSLQETSSIVSVPSEAVDNV
ENVVSFNAKEHENFLETIQEQQTTESAGQDLISIPKAVEPMEIDSEESESDGSFIEVQSV
ISDEELQAEFPETSKPPSEQGEEELVGTREGEAPAESESLLRDNSERDDVDGEPQEAEKD
AEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFLESQELLRLFG
IPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRNFFNKNKFVEYYQYVDF
HNQLGLDRNKLINLAYLLGSDYTEGIPTVGCVTAMEILNEFPGHGLEPLLKFSEWWHEAQ
KNPKIRPNPHDTKVKKKLRTLQLTPGFPNPAVAEAYLKPVVDDSKGSFLWGKPDLDKIRE
FCQRYFGWNRTKTDESLFPVLKQLDAQQTQLRIDSFFRLAQQEKEDAKRIKSQRLNRAVT
CMLRKEKEAAASEIEAVSVAMEKEFELLDKAKGKTQKRGITNTLEESSSLKRKRLSDSKG
KNTCGGFLGETCLSESSDGSSSEDAESSSLMNVQRRTAAKEPKTSASDSQNSVKEAPVKN
GGATTSSSSDSDDDGGKEKMVLVTARSVFGKKRRKLRRARGRKRKT
NT seq 3561 nt   +upstreamnt  +downstreamnt
atgggggtccaggggctctggaagctgctggagtgctccgggcggcaggtcagccccgaa
gcgctggaagggaagatcctggctgttgatattagcatttggttaaaccaagcacttaaa
ggagtccgggatcgccatgggaactcaatagaaaatcctcatcttctcactttgtttcat
cggctctgcaaactcttattttttcgaattcgtcctatttttgtgtttgatggggatgct
ccactattgaagaaacagactttggtgaagagaaggcagagaaaggacttagcgtccagt
gactccaggaaaacgacagagaagcttctgaaaacatttttgaaaagacaagccatcaaa
actgccttcagaagcaaaagagatgaagcactacccagtcttacccaagttcgaagagaa
aacgacctctatgttttgcctcctttacaagaggaagaaaaacacagttcagaagaggaa
gatgaaaaagaatggcaagaaagaatgaatcaaaaacaagcattacaggaagagttcttt
cataatcctcaagcgatagatattgagtctgaggacttcagcagcctgccccctgaagta
aagcatgaaatcttgactgatatgaaagagttcaccaagcgcagaagaacattatttgaa
gcaatgccagaggagtctgatgacttttcacagtaccaactcaaaggcttgcttaaaaag
aactatctgaaccagcatatagaacatgtccaaaaggaaatgaatcagcaacattcagga
cacatccgaaggcagtatgaagatgaagggggctttctgaaggaggtagagtcaaggaga
gtggtctctgaagacacttcacattacatcttgataaaaggtattcaagctaagacagtt
gcagaagtggattcagagtctcttccttcttccagcaaaatgcacggcatgtcttttgac
gtgaagtcatctccatgtgaaaaactgaagacagagaaagagcctgatgctacccctcct
tctccaagaactttactagctatgcaagctgccctgctgggaagtagctcagaagaggag
ctggagagtgaaaatcgaaggcaggcccgtgggaggaacgcacctgctgctgtagacgaa
ggctccatatcaccccggactctttcagccattaagagagctcttgacgatgacgaagat
gtaaaagtgtgtgctggggatgatgtgcagacgggagggccaggagcagaagaaatgcgt
ataaacagctccaccgagaacagtgatgaaggacttaaagtgagagatggaaaaggaata
ccgtttactgcaacacttgcgtcatctagtgtgaactctgcagaggagcacgtagccagc
actaatgaggggagagagcccacagactcagttccaaaagaacaaatgtcacttgttcac
gtggggactgaagcctttccgataagtgatgagtctatgattaaggacagaaaagatcgg
ctgcctctggagagtgcagtggttagacatagtgacgcacctgggctcccgaatggaagg
gaactgacaccggcatctccaacttgtacaaattctgtgtcaaagaatgaaacacatgct
gaagtgcttgagcagcagaacgaactttgcccatatgagagtaaattcgattcttctctt
ctttcaagtgatgatgaaacaaaatgtaaaccgaattctgcttctgaagtcattggccct
gtcagtttgcaagaaacaagtagcatagtaagtgtcccttcagaggcagtagataatgtg
gaaaatgtggtgtcatttaatgctaaagagcatgagaattttctggaaaccatccaagaa
cagcagaccactgaatctgcaggccaggatttaatttccattccaaaggccgtggaacca
atggaaattgactcggaagaaagtgaatctgatggaagtttcattgaagtgcaaagtgtg
attagtgatgaggaacttcaagcagaattccctgaaacttccaaacctccctcagaacaa
ggcgaagaggaactggtaggaactagggagggagaagcccctgctgagtccgagagcctc
ctgagggacaactctgagagggacgacgtggatggtgagccacaggaagctgagaaagat
gcggaagattcgctccatgaatggcaagatattaatttggaggagttggaaactctggag
agcaacctcttagcacagcagaattcactgaaagctcaaaaacagcagcaagaacggatc
gctgctactgtcaccggacagatgttcctggaaagccaggaactcctgcgcctgttcggc
attccctacatccaggctcccatggaagcagaggcgcagtgcgccatcctggacctgact
gatcagacttccggaaccatcactgatgacagtgatatctggctgtttggagcgcggcat
gtctatagaaacttttttaataaaaacaagtttgtagaatattatcaatatgtggacttt
cacaatcaattgggattggaccggaataagttaataaatttggcttatttgcttggaagt
gattataccgaaggaataccaactgtgggttgtgtaaccgccatggaaattctcaatgaa
ttccctgggcatggcctggaacctctcctaaaattctcagaatggtggcatgaagctcaa
aaaaatccaaagataagacctaatcctcatgacaccaaagtgaaaaaaaaattacggaca
ttgcaactcacccctggctttcctaacccagctgttgccgaggcctacctcaaacccgtg
gtggatgactcgaagggatcctttctgtgggggaaacctgatctcgacaaaattagagaa
ttttgtcagcggtatttcggctggaacagaacgaagacagatgaatctctgtttcctgta
ttaaagcaactcgatgcccagcagacacagctccgaattgattccttctttagattagca
caacaggagaaagaagatgctaaacgtattaagagccagagactaaacagagctgtgaca
tgtatgctaaggaaagagaaagaagcagcagccagcgaaatagaagcagtttctgttgcc
atggagaaagaatttgagctacttgataaggcaaaaggaaaaacccagaagagaggcata
acaaataccttagaagagtcatcaagcctgaaaagaaagaggctttcagattctaaagga
aagaatacatgcggtggatttttgggggagacctgcctctcagaatcatctgatggatct
tcaagtgaagatgctgaaagttcatctttaatgaatgtacaaaggagaacagctgcgaaa
gagccaaaaaccagtgcttcagattcgcagaactcagtgaaggaagctcccgtgaagaat
ggaggtgcgaccaccagcagctctagtgatagtgatgacgatggagggaaagagaagatg
gtcctcgtgaccgccagatctgtgtttgggaagaaaagaaggaaactaagacgtgcgagg
ggaagaaaaaggaaaacctaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (7)   
   KEGG DISEASE (4)   
   OMIM (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (29)   
   RefSeq(nuc) (1)   
   GenBank (14)   
   EMBL (14)   
3D Structure (7)   
   PDB (7)   
Protein domain (4)   
   Pfam (4)   
All databases (84)   

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